In the sequel to Interview with a Vampire, the vampire Lestat has returned once again. Lestat has been asleep for over a hundred years, and when he wakes he has a new plan for his future. He wants to be in the spot light, and the way he decides to do this is by the usage of rock music. As the vampire Lestat starts his music career, other vampires don't approve of what he's doing because vampires are supposed to remain in the shadows. With his music, he awakens Akasha, the Queen of the Damned. Now Akasha wants to make Lestat her king and destroy everything that stands in her way.
The movie opens with us being introduced to Lestat as he awakens from his hundred years of sleep. When he wakes up he decides to visit his old house, and there he finds the rock band practicing in his home. He decides to become the lead singer of this band and together they will be above the normal people. Soon we meet Jesse, a girl who has a fascination for vampires. She learns about the past and we see how Lestat came to be, and how his connection to Akasha ...